The Nike Interact Run and Nike Run Defy are both neutral road running shoes. The Interact Run is 0.8 oz lighter (7.4 oz vs 8.2 oz). The Run Defy costs about $35 less (from $49.97).
Bottom line: Pick the Interact Run if you want the lighter shoe; pick the Run Defy if you want to spend less.
Specs side by side
| Spec | Interact Run | Run Defy |
|---|---|---|
| Price | $85 | $49.97–$65 |
| Rating | — | 4.7 / 5 (240 reviews) |
| Weight | 7.4 oz | 8.2 oz |
| Heel-to-toe drop | 10 mm | 10 mm |
| Support | Neutral | Neutral |
| Surface | Road | Road |
| Available for | Women | Men & Women |
Specs and prices from Nike, checked 2026-11-02. Weight is usually for a men's size 9–10.
Which should you get?
Get the Interact Run if…
- you want the lighter shoe
Get the Run Defy if…
- you want to spend less
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